About Restylane® and Perlane® injectable gels

How does Restylane work?

Restylane adds volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Restylane can also add fullness and definition to lips in patients over 21 years, providing natural-looking and lasting results with just one treatment. Learn more about Restylane for lip enhancement.

Restylane works immediately by adding volume to smooth away wrinkles. A clear gel formulation of hyaluronic acid, Restylane is specifically formulated to act like your body's own hyaluronic acid. So, you can use Restylane to visibly reduce moderate to severe facial wrinkles and folds, and to add fullness to your lips.

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Treatment volume should be limited to 6.0 mL in wrinkles and folds, such as nasolabial folds, and limited to 1.5 mL per lip (Restylane only), as greater amounts significantly increase moderate and severe injection site reactions. If a volume of more than 3 mL total is needed to achieve optimal correction for lip enhancement, a follow-up treatment session is recommended.

Biocompatible with the human body, Restylane is eventually broken down naturally.

How does Perlane work?

Just like Restylane, Perlane adds volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds).

Like Restylane, Perlane is a clear gel formulation of hyaluronic acid that is specifically formulated to add volume like your body's own hyaluronic acid.

What makes Perlane different is the average size of the particles and the depth of injection. On average, the gel particles in Perlane are larger than those in Restylane, which makes Perlane a good choice for wrinkles that benefit from a deeper injection into the skin.

In three clinical studies of 150 patients each, on average 70% of patients maintained improvement for six months after just one Perlane treatment.

During your consultation, your healthcare professional will decide which product is right for you.

Next: About Restylane-L® and Perlane-L® Injectable Gels

The Restylane family of products includes Restylane, Restylane-L, Perlane, and Perlane-L. These products can be used to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Restylane and Restylane-L may also be used for lip enhancement in patients over 21 years. Ask your doctor which is right for you.

Important Safety Considerations for the Restylane family of products

Products in the Restylane family should not be used by people with previous bad allergies, particularly to microorganisms known as gram-positive bacteria, or by people with serious allergies to drugs that have previously required in-hospital treatment. These products should not be used by people with bleeding disorders. Products should not be injected anywhere except the skin, just under the skin (Perlane and Perlane-L only), or in the lips (Restylane and Restylane-L only). Restylane-L and Perlane-L should not be used by anyone with a known allergy to lidocaine.

Use at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. In these instances, product use could delay healing or make your skin problems worse. After treatment, you might have some swelling, redness, pain, bruising, or tenderness. These are typically mild in severity and normally last less than 7 days in nasolabial folds and less than 14 days in lips. Swelling may be more likely in patients under 36 years, and bruising may be more likely in patients over 35 years. Rarely, the doctor may inject into a blood vessel, which can damage the skin. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause an outbreak. To avoid bruising and bleeding, you should not use the products if you have recently used drugs that thin your blood or prevent clotting. Products should not be used during pregnancy, when breastfeeding, or in patients under 18 years for nasolabial folds.

Treatment volume should be limited to 6.0 mL in wrinkles and folds, such as nasolabial folds, and limited to 1.5 mL per lip (Restylane and Restylane-L only), as greater amounts significantly increase moderate and severe injection site reactions. The safety or effectiveness of treatment in areas other than nasolabial folds and lips (Restylane and Restylane-L only) has not been established in controlled clinical studies.

Medicis Aesthetics

The Restylane family of products is available only through a licensed practitioner.

The Restylane Family

For Moderate to Severe
Wrinkles & Folds

For Lip Enhancement in
Patients Over 21

Before & After Gallery

Resources & Rewards

Restylane, Restylane-L, Perlane, Perlane-L, and Restylane Rewards are registered trademarks of HA North American Sales AB. All other trademarks are the property of their respective owners. RES 12-032R2