Actual patient. Individual results may vary.
Restylane® Defyne
Defyne your look from every angle
Define your look from
every angle
Restylane Defyne is a hyaluronic acid (HA) filler that helps to soften deep laugh lines, such as nasolabial folds, and can be used to define the shape of the chin. Restylane Defyne can correct mild-to-moderate chin retrusion, with 98% of patients having improved double chin appearance after treatment.1,2*†
*Patients (clinical trial subjects; N=60) were treated with Restylane Defyne in the nasolabial folds (NLFs), Marionette lines (MLs), and Chin in a clinical study
†Results 9 weeks after treatment with Restylane Defyne.
†Results 9 weeks after treatment with Restylane Defyne.
Dynamic support
Restylane Defyne is designed to help support your facial expressions—for natural-looking results that help maintain your natural facial movement.1,3
Scroll to see Amanda’s results after treatment with Restylane Defyne
Bring your look into proportion
Minimally invasive chin augmentation with Restylane Defyne can bring balance to the profile with correction of a “weak chin,” in addition to improving the appearance of facial symmetry.1,5
Amanda was treated with 3 mL of Restylane Defyne in the chin.
Explore more Before & After photos
Explore unretouched images of real people who chose Restylane for natural-looking results that are still true to them.
Adriana was treated with 2.6 mL of Restylane Defyne in the chin. Actual patient. One week after treatment. Individual results may vary.
Real people. Real results.
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100%of patients had improved facial harmony after treatment with Restylane Defyne.2*
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98%of patients had improved double chin appearance after treatment with Restylane Defyne.2*
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95%of patients reported feeling satisfied with their facial symmetry after treatment.2*
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97%of patients reported feeling satisfied with how balanced their face looked after treatment.2*
Frequently Asked Questions
For patients with a "weak chin" and a round face, chin filler can be used to augment the chin projection, which will lessen the appearance of roundness of the face, resulting in a more heart- or oval-shaped appearance.1-2
A double chin may emphasize the roundedness of a face’s shape. Restylane Defyne can be used to reduce the appearance of a double chin.1,3*
References:
- Restylane Defyne. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Vanaman Wilson MJ, Jones IT, Butterwick K, Fabi SG. Role of nonsurgical chin augmentation in full face rejuvenation: a review and our experience. Dermatol Surg. 2018;44(7):985-993.
- Data on file. 05DF1910 Clinical Study Report. Galderma Laboratories, L.P., 2022.
*Patients (clinical trial subjects; N=60) were treated with Restylane Defyne in the nasolabial
folds (NLFs), Marionette lines (MLs), and Chin in a clinical study.
Most Restylane appointments last less than an hour, and results can be seen almost immediately as the added volume begins to smooth away wrinkles.
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References
- Restylane Defyne. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Data on file. 05DF1910 Clinical Study Report. Galderma Laboratories, L.P., 2022.
- Segura S, Anthonioz L, Fuchez F, Herbage B. A complete range of hyaluronic acid filler with distinctive physical properties specifically designed for optimal tissue adaptations. J Drugs Dermatol. 2012;11(Suppl 1):s5-s8.
- Philipp-Dormston WG, Schuster B, Podda M. Perceived naturalness of facial expression after hyaluronic acid filler injection in nasolabial folds and lower face. J Cosmet Dermatol. 2020;19:1600-1606.
- Vanaman Wilson, et al. Role of nonsurgical chin augmentation in full face rejuvenation: a review and our experience. Dermatol Surg. 2018;00:1-9.
Instructions for Use
Patient Safety Information
Important Safety Information
The Restylane family of products are indicated for patients over the age of 21, and includes Restylane®, Restylane-L®, Restylane® Lyft with Lidocaine, Restylane® Silk, Restylane® Kysse, Restylane® Refyne, Restylane® Defyne, Restylane® Contour, and Restylane® Eyelight.
Approved Uses
Restylane® and Restylane-L® are for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. Restylane® and Restylane-L® are also indicated for injection into the lips.
Restylane® Lyft with Lidocaine is for deep implantation into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds and for cheek augmentation and for the correction of age-related midface contour deficiencies. Restylane® Lyft with Lidocaine is also indicated for injection into the dorsal hand to correct volume loss.
Restylane® Silk is for lip augmentation and for correction of perioral wrinkles.
Restylane® Kysse is for lip augmentation and for correction of upper perioral wrinkles.
Restylane® Refyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds.
Restylane® Defyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe deep facial wrinkles and folds, such as nasolabial folds. Restylane® Defyne is also indicated for injection into the mid-to-deep dermis (subcutaneous and/or supraperiosteal) for augmentation of the chin region to improve the chin profile in patients with mild to moderate chin retrusion.
Restylane® Contour is for cheek augmentation and for the correction of midface contour deficiencies.
Restylane® Eyelight is for the improvement of infraorbital hollowing.
Do not use if you have severe allergies with a history of severe reactions (anaphylaxis), are allergic to lidocaine or gram-positive bacterial proteins used to make hyaluronic acid, prone to bleeding, or have a bleeding disorder. The safety of use while pregnant or breastfeeding has not been studied. Tell your doctor if you have a history of scarring or pigmentation disorders as these side effects can occur with hyaluronic acid fillers. Tell your doctor if you are planning other cosmetic treatments (i.e., lasers and chemical peels) as there is a possible risk of inflammation at the injection site.
Tell your doctor if you’re taking medications that lower your body’s immune response or affect bleeding, such as aspirin or warfarin, as these medications may increase the risk of bruising or bleeding at the gel injection site. Using these products on gel injection sites with skin sores, pimples, rashes, hives, cysts, or infections should be postponed until healing is complete.
The most common side effects are swelling, redness, pain, bruising, headache, tenderness, lump formation, itching at the injection site, and impaired hand function. Delayed-onset inflammation near the site of dermal filler injections is one of the known adverse events associated with dermal fillers, and cases have been reported to occur at the dermal filler treatment site following viral or bacterial illnesses or infections, vaccinations, or dental procedures. Typically, the reported inflammation was responsive to treatment or resolved on its own. Serious but rare side effects include delayed onset infections, recurrence of herpetic eruptions, and superficial necrosis at the injection site. The risk of unintentional injection into a blood vessel is small but can occur and could result in serious complications, which may be permanent including, vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. As with all skin injection procedures, there is a risk of infection.
To report a side effect with any Restylane® product, please call Galderma Laboratories, L.P. at 1-855-425-8722.
To learn more about serious but rare side effects and full Important Safety Information, visit www.RestylaneUSA.com.