The original hyaluronic acid gel dermal filler

Restylane has over 26 years of clinically proven safety worldwide, and efficacy for diverse skin colors and types fillers.1-3
HA gel used in Restylane® Fillers

Reveal a younger-looking you

Specifically formulated to act like your body's own naturally produced hyaluronic acid, Restylane provides support and structure in the lips and smile lines.1

Real people. Real results.

  • 95%
    of people treated with Restylane still saw improvement after 18 months.1*†
95%
of people treated with Restylane still saw improvement after 18 months.1*†
brand
*Subjects were re-treated at 4.5 and/or 9 months.
†In a clinical study of subjects treated with Restylane, blinded evaluators reported still seeing improvement in 95% of subjects 18 months after initial injection. Use at the site of skin sores, pimples, rashes, hives, cysts, or infections should be postponed until healing is complete. In these instances, product use could delay healing or make your skin problems worse.

Frequently Asked Questions

Dermal fillers are injectable treatments that can help to diminish the appearance of wrinkles while restoring volume and fullness in the face and hands, or to re-shape features to meet aesthetic goals, such as achieving a fuller lip or correcting the appearance of a recessed chin.1,2

There are several types of dermal fillers, one being hyaluronic acid (HA). All Restylane fillers use HA gel technology made of transparent hyaluronic acids, which are sugars naturally found in the skin that help provide hydration, fullness, and elasticity.

References:
  • Vleggaar D, Fitzgerald R. Dermatological implications of skin aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7:209-220.
  • Data on file. Galderma Laboratories, L.P.

Most Restylane appointments last less than an hour, and results can be seen almost immediately as the added volume begins to smooth away wrinkles.

As we age, our skin changes, becoming thinner, losing fat, and no longer looking as plump or smooth as it once did. Facial aging begins in your 20s, when skin firmness starts decreasing as a result of both internal factors (i.e., genetics and natural aging) and external factors (e.g., sun exposure, smoking, stress).1 Hyaluronic acid (HA), collagen, and elastin diminish as we age, causing skin to lose volume and increasing the chances for wrinkles and folds to appear.1 Restylane dermal fillers use a clear gel formulation of HA.

References:
  • Vleggaar D, Fitzgerald R. Dermatological implications of skin aging: a focus on supraperiosteal volumization for perioral rejuvenation. J. Drugs Dermatol. 2008;7:209-220.
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References
  1. Restylane. Instructions for Use. Galderma Laboratories, L.P., 2023.
  2. Data on file. MA-48087 Report. Galderma Laboratories, L.P., 2021.
  3. Data on file. MA-39680 Report. Galderma Laboratories, L.P., 2021.
Instructions for Use
Patient Safety Information
Important Safety Information

The Restylane family of products are indicated for patients over the age of 21, and includes Restylane®, Restylane-L®, Restylane® Lyft with Lidocaine, Restylane® Silk, Restylane® Kysse, Restylane® Refyne, Restylane® Defyne, Restylane® Contour, and Restylane® Eyelight.

Approved Uses

Restylane® and Restylane-L® are for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. Restylane® and Restylane-L® are also indicated for injection into the lips.

Restylane® Lyft with Lidocaine is for deep implantation into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds and for cheek augmentation and for the correction of age-related midface contour deficiencies. Restylane® Lyft with Lidocaine is also indicated for injection into the dorsal hand to correct volume loss.

Restylane® Silk is for lip augmentation and for correction of perioral wrinkles.

Restylane® Kysse is for lip augmentation and for correction of upper perioral wrinkles.

Restylane® Refyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds.

Restylane® Defyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe deep facial wrinkles and folds, such as nasolabial folds. Restylane® Defyne is also indicated for injection into the mid-to-deep dermis (subcutaneous and/or supraperiosteal) for augmentation of the chin region to improve the chin profile in patients with mild to moderate chin retrusion.

Restylane® Contour is for cheek augmentation and for the correction of midface contour deficiencies.

Restylane® Eyelight is for the improvement of infraorbital hollowing.

Do not use if you have severe allergies with a history of severe reactions (anaphylaxis), are allergic to lidocaine or gram-positive bacterial proteins used to make hyaluronic acid, prone to bleeding, or have a bleeding disorder. The safety of use while pregnant or breastfeeding has not been studied. Tell your doctor if you have a history of scarring or pigmentation disorders as these side effects can occur with hyaluronic acid fillers. Tell your doctor if you are planning other cosmetic treatments (i.e., lasers and chemical peels) as there is a possible risk of inflammation at the injection site.

Tell your doctor if you’re taking medications that lower your body’s immune response or affect bleeding, such as aspirin or warfarin, as these medications may increase the risk of bruising or bleeding at the gel injection site. Using these products on gel injection sites with skin sores, pimples, rashes, hives, cysts, or infections should be postponed until healing is complete.

The most common side effects are swelling, redness, pain, bruising, headache, tenderness, lump formation, itching at the injection site, and impaired hand function. Delayed-onset inflammation near the site of dermal filler injections is one of the known adverse events associated with dermal fillers, and cases have been reported to occur at the dermal filler treatment site following viral or bacterial illnesses or infections, vaccinations, or dental procedures. Typically, the reported inflammation was responsive to treatment or resolved on its own. Serious but rare side effects include delayed onset infections, recurrence of herpetic eruptions, and superficial necrosis at the injection site. The risk of unintentional injection into a blood vessel is small but can occur and could result in serious complications, which may be permanent including, vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. As with all skin injection procedures, there is a risk of infection.

To report a side effect with any Restylane® product, please call Galderma Laboratories, L.P. at 1-855-425-8722.

To learn more about serious but rare side effects and full Important Safety Information, visit www.RestylaneUSA.com.

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