Restylane Portfolio
The Restylane family of products is a brand of hyaluronic acid (HA) dermal fillers designed for natural-looking results. Each product is a clear gel formulation of HA specifically formulated to act like your body's own naturally produced HA. Each Restylane product is designed for a specific purpose.1-9 The portfolio includes:
- Restylane®
- Restylane-L
- Restylane Lyft
- Restylane Silk
- Restylane Kysse
- Restylane Refyne
- Restylane Defyne
- Restylane Contour
- Restylane Eyelight
Restylane products are indicated only for patients over the age of 21.
- Restylane. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane-L. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Lyft. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Silk. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Kysse. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Refyne. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Defyne. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Contour. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Eyelight. Instructions for Use. Galderma Laboratories, L.P., 2023.
Results will vary depending on the product, your individual body chemistry (your metabolism) and the amount of product used, but here are some general ideas of duration, based on clinical studies:
- Restylane and Restylane-L: Results from treatment with Restylane and Restylane-L in facial wrinkles and folds have been shown to last up to 18 months.1,2
- Restylane Contour: Results from treatment of the cheeks with Restylane Contour have been shown to last up to 18 months.3
- Restylane Kysse: Results from treatment with Restylane Kysse in the lips have been shown to last for up to 1 year.4,5
- Restylane Defyne: Results from treatment with Restylane Defyne have been shown to last up to 1 year for facial wrinkles and folds, like nasolabial folds and marionette lines, as well as the chin.6,7
- Restylane Lyft: Results have been shown to last up to 1 year with Restylane Lyft in the cheeks; up to 6 months in facial wrinkles and folds, like nasolabial folds; and up to 6 months in the hands.8
- Restylane Refyne: Results from treatment with Restylane Refyne have been shown to last up to 1 year for facial wrinkles and folds, like nasolabial folds and marionette lines.9
- Restylane Silk: Results from treatment with Restylane Silk have been shown to last up to 6 months for lips and perioral rhytids (wrinkles around the mouth).10
- Restylane Eyelight: Results from treatment with Restylane Eyelight in the undereye area have been shown to last up to 18 months with optimal treatment.11
- Restylane. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane-L. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Contour. Instructions for Use. Galderma Laboratories, L.P., 2023
- Restylane Kysse. Instructions for Use. Galderma Laboratories, L.P., 2023
- Hilton S, Sattler G, Berg AK, Samuelson U, Wong C. Randomized, evaluator-blinded study comparing safety and effect of two hyaluronic acid gels for lips enhancement. Dermatol Surg. 2018;44:261-269.
- Restylane Defyne. Instructions for Use. Galderma Laboratories, L.P., 2023
- Data on file. 43USCH1702 Clinical Study Report. Galderma Laboratories, L.P., 2020.
- Restylane Lyft. Instructions for Use. Galderma Laboratories, L.P., 2023
- Restylane Refyne. Instructions for Use. Galderma Laboratories, L.P., 2023
- Restylane Silk. Instructions for Use. Galderma Laboratories, L.P., 2023
- Restylane Eyelight. Instructions for Use. Galderma Laboratories, L.P., 2023.
Yes! Please explore our Gallery of patient results.
After your treatment, you may experience common side effects, which can include:
- Swelling
- Redness
- Pain
- Bruising
- Headache
- Tenderness
- Lump formation
- Itching at the injection site
- Impaired hand function
These are typically mild in severity and normally last less than 7 days in nasolabial folds and less than 14 to 18 days in the lips.
Patients should be limited to 6 mL per treatment of moderate-to-severe facial wrinkles and folds. For treatment of volume deficit in the hands, patients should be limited to 3 mL per hand per treatment.
Swelling may be more likely in patients under 36 years of age, and bruising may be more likely in patients over 35 years of age. Please see below the Important Safety Considerations for the Restylane family of products.
Restylane products should not be used by people who1-9:
- Are pregnant, breastfeeding, or under 22 years of age
- Have recently used drugs that thin the blood or prevent clotting
- Have had previous bad allergies, particularly to microorganisms known as gram-positive bacteria
- Have serious allergies to drugs that have previously required in-hospital treatment
- Have bleeding disorders
- Have a known allergy to lidocaine (Restylane-L, Restylane Lyft, Restylane Silk, Restylane Kysse, Restylane Refyne, Restylane Defyne, Restylane Contour, and Restylane Eyelight all contain lidocaine. Restylane is the only product that does not contain lidocaine)
- Restylane. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane-L. Instructions for Use. Galderma Laboratories, L.P., 2023
- Restylane Lyft. Instructions for Use. Galderma Laboratories, L.P., 2023
- Restylane Silk. Instructions for Use. Galderma Laboratories, L.P., 2023
- Restylane Kysse. Instructions for Use. Galderma Laboratories, L.P., 2023
- Restylane Refyne. Instructions for Use. Galderma Laboratories, L.P., 2023
- Restylane Defyne. Instructions for Use. Galderma Laboratories, L.P., 2023
- Restylane Contour. Instructions for Use. Galderma Laboratories, L.P., 2023
- Restylane Eyelight. Instructions for Use. Galderma Laboratories, L.P., 2023.
Fillers | Treatment | Aging
Dermal fillers are injectable treatments that can help to diminish the appearance of wrinkles while restoring volume and fullness in the face and hands, or to re-shape features to meet aesthetic goals, such as achieving a fuller lip or correcting the appearance of a recessed chin.1,2
There are several types of dermal fillers, one being hyaluronic acid (HA). All Restylane fillers use HA gel technology made of transparent hyaluronic acids, which are sugars naturally found in the skin that help provide hydration, fullness, and elasticity.1
- Vleggaar D, Fitzgerald R. Dermatological implications of skin aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7:209-2202.
- Data on file. Galderma Laboratories, L.P.
Hyaluronic acid (HA) is a naturally occurring substance in your skin that helps provide hydration, fullness, and elasticity. It diminishes as we age, causing skin to lose volume while increasing the chances for wrinkles and folds to appear.1
Restylane dermal fillers use a clear gel formulation of HA. Restylane was the first non-animal stabilized HA dermal filler to be approved by the US FDA, and has been used in over 65 million treatments worldwide.2
- Vleggaar D, Fitzgerald R. Dermatological implications of skin aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7:209-220.
- Data on file. MA-39680. Global 65 Million Restylane Treatments, 2023.
As we age, our skin changes, becoming thinner, losing fat, and no longer looking as plump or smooth as it once did. Facial aging begins in your 20s, when skin firmness starts decreasing as a result of both internal factors (i.e., genetics and natural aging) and external factors (e.g., sun exposure, smoking, stress).1
Hyaluronic acid (HA), collagen, and elastin diminish as we age, causing skin to lose volume and increasing the chances for wrinkles and folds to appear.1 Restylane dermal fillers use a clear gel formulation of HA.
- Vleggaar D, Fitzgerald R. Dermatological implications of skin aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7:209-220.
Most Restylane appointments last less than an hour, and results can be seen almost immediately as the added volume begins to smooth away wrinkles.
Initial Restylane treatments are usually complete in one or two sessions, as needed. Depending on your individual body chemistry, you will work with your specialist to determine a maintenance schedule. We always recommend talking to your aesthetic injector or healthcare professional about your individual needs and beauty goals.
- Data on file. Analysis of consumer social media conversation/digital behaviors. Galderma Laboratories, L.P. 2023.
- Data on file. GLI.04.US.SL.024 Clinical Study Report. Galderma Laboratories, L.P. 2023.
†Percent very satisfied or satisfied with question.
- Kablik J, Monheit GD, Yu L, Chang G, Gershkovich J. Comparative physical properties of hyaluronic acid dermal fillers. Dermatol Surg. 2009;35(suppl 1):302-312.
- Data on file. MA-34483 Study Report. Galderma Laboratories, L.P. 2021.
- Data on file. MA-53297 Study Report. Galderma Laboratories, L.P. 2022.
- Kablik J, Monheit GD, Yu L, Chang G, Gershkovich J. Comparative physical properties of hyaluronic acid dermal fillers. Dermatol Surg. 2009;35(suppl 1):302-312.
- Cleveland Clinic. Dark Circles Under Eyes. Cleveland Clinic Health Library. Updated May 25, 2022. Accessed April 2023. https://my.clevelandclinic.org/health/symptoms/23128-dark-circles-under-eyes
- Restylane Eyelight. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Data on file. 43USTT1904 Clinical Study Report. Galderma Laboratories, L.P., 2022.
†Patient=clinical trial subject.
‡Percent very satisfied or satisfied with question.
Results may vary depending on your individual body chemistry (metabolism) and the amount of product used. The Restylane Family has several lip fillers, including Restylane Kysse, Restylane Silk, Restylane, and Restylane-L.1-5 Restylane Kysse is clinically proven to last up to 1 year.1-2 Talk to your injector about the best treatment plan for you.
- Restylane Kysse. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Hilton S, Sattler G, Berg AK, Samuelson U, Wong C. Randomized, evaluator-blinded study comparing safety and effect of two hyaluronic acid gels for lips enhancement. Dermatol Surg. 2018;44:261-269.
- Restylane. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane-L. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Silk. Instructions for Use. Galderma Laboratories, L.P., 2023.
Everyone’s facial structure is different, and so are everyone’s ideal lip shape and size. Restylane-L, Restylane Silk and Restylane Kysse are designed to provide precise lip shaping and line control, resulting in natural-looking results.1,2,4,5
- Restylane Kysse. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Philipp-Dormston WG, Wong C, Schuster B, Larsson M, Podda M. Evaluating perceived naturalness of facial expression after fillers to the nasolabial folds and lower face with standardized video and photography. Dermatol Surg. 2018;44(6):826-832
- Data on file. 05DF1807 Clinical Study Report. Galderma Laboratories, L.P., 2020.
- Restylane-L. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Silk. Instructions for Use. Galderma Laboratories, L.P., 2023.
The amount of lip filler you need will vary based on your goals, natural lip size, and other factors. The best way to determine the amount of lip filler you’ll need is to meet an aesthetic injector for an in-person consultation. Each syringe of Restylane lip filler contains 1 mL of hyaluronic acid (HA) gel.
In our Results Gallery, you will find Before & After photos of Restylane patients who received varying amounts of lip filler depending on the product used, from 0.75 mL to 1 syringe (or 1 mL), and up to 1.95 mL, while still achieving natural-looking results.
Here are some useful tips for lip filler aftercare:
- Use cold compresses to reduce swelling.
- If you have a history of cold sores, talk with your injector before your appointment about medications that may minimize the likelihood of an outbreak. Needle punctures to the lip may increase the likelihood of cold sore reoccurrence.
- Avoid taking aspirin, nonsteroidal anti-inflammatory medications (such as ibuprofen), St. John's wort or high doses of vitamin E supplements.1,2 These agents may increase bruising and bleeding at the injection site.
- Minimize strenuous exercise and exposure to excessive heat, sun, or UV lamps for the first 24 hours after treatment. Exposure to any of these may cause temporary redness, swelling, and/or itching at the injection site. Until there is no redness or swelling, avoid exposure of the treated area to intense cold or heat such as sun lamps or sunbathing.
Remember to ask about follow-up appointments and for any additional aftercare instructions from your injector.
- Restylane Silk. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Kysse. Instructions for Use. Galderma Laboratories, L.P., 2023.
Your aesthetic goals will impact the amount of cheek filler needed for treatment. Talk to your injector about what you’re looking for, whether it’s the appearance of dramatically lifted and defined cheekbones (Restylane Lyft1) or subtly reclaiming the contour of cheeks (Restylane Contour2).
When studied in a clinical setting, the average volume of Restylane Lyft used for cheek augmentation was 3 mL total (3 syringes) at initial treatment, or roughly 1.5 mL per cheek. The average amount used in a study using Restylane Contour to restore midface volume loss was 3.8 mL, or 1.9 syringes per side.
In our Results Gallery, you will find Before & After photos of patients who received as little as 0.5 mL of Restylane Lyft per cheek, or as much as 1.5 mL per cheek. Before & After photos of patients who received Restylane Contour treatment show a range of 1 mL to 2 mL used per cheek.
- Restylane Lyft. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Contour. Instructions for Use. Galderma Laboratories, L.P., 2023.
Restylane Results may vary depending on your individual body chemistry (metabolism) and the amount of product used. The Restylane Family has two cheek fillers - Restylane Contour1 and Restylane Lyft.2
Restylane Contour has been clinically proven to improve midface cheek contour for up to 18 months.1,3
Restylane Lyft has been clinically proven to increase fullness in the cheeks for up to 12 months.2
- Restylane Contour. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Lyft. Instructions for Use. Galderma Laboratories, L.P., 2023
- Data on file. Fort Worth, TX: Galderma Laboratories, L.P.
Chin filler is used for minimally invasive (non-surgical) augmentation of the chin to improve the chin’s projection or shape. Restylane Defyne can be used to reduce the appearance of a double chin, or correct mild-to-moderate chin retrusion, sometimes called a “weak chin.”1,2*
Chin filler can also be used to bring balance to the lower third of the face when a larger-sized lip look is the aesthetic goal. If a “weak chin” is out of proportion with a large lip, the enhancement of the chin will bring these two features into proportion for better harmony of facial features.3
Chin filler has been used in minimally invasive (non-surgical) gender-affirming care as well. The shape of the chin can have a “more traditionally masculine” shape, or a “more traditionally feminine” shape. Filler can help in achieving such looks.4
- Restylane Defyne. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Data on file. 05DF1910 Clinical Study Report. Galderma Laboratories, L.P., 2023.
- Vanaman Wilson, et al. Role of nonsurgical chin augmentation in full face rejuvenation: a review and our experience. Dermatol Surg. 2018;00:1-9.
- MacGregor JL, Chang YC. Minimally invasive procedures for gender affirmation. Dermatol Clin. 2020 Apr;38(2):249-260.
In a clinical study of people who received Restylane Defyne in the chin, those that reported some level of swelling reported it lasting between 1 and 7 days.1
The occurrence of swelling and the degree of swelling vary for each individual. Swelling may be more likely in patients under 36 years.
- Restylane Defyne. Instructions for Use. Galderma Laboratories, L.P., 2023.
The amount of chin filler used will vary based on your goals. Based on clinical studies, for augmentation of the chin region to improve the chin profile, the maximum recommended injected volume per patient and treatment is 4 mL (i.e., 2 mL in the chin and 2 mL in the area inferior to the lower lip, between the two lines from oral commissures up to the pre-jowl sulcus).1 The safety of injecting greater amounts has not been established.
In our Results Gallery, we have Before & After photos of chin filler patients.
- Restylane Defyne. Instructions for Use. Galderma Laboratories, L.P., 2023.
For patients with a "weak chin" and a round face, chin filler can be used to augment the chin projection, which will lessen the appearance of roundness of the face, resulting in a more heart- or oval-shaped appearance.1-2
A double chin may emphasize the roundedness of a face’s shape. Restylane Defyne can be used to reduce the appearance of a double chin.1,3*
- Restylane Defyne. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Vanaman Wilson, et al. Role of nonsurgical chin augmentation in full face rejuvenation: a review and our experience. Dermatol Surg 2018;00:1-9.
- Data on file. 05DF1910 Clinical Study Report. Galderma Laboratories, L.P., 2022.
When studied in a clinical setting, side effects that occurred at the injection site for the use of Restylane Defyne in the chin included swelling, small bumps, redness, pain, tenderness, bruising, and itching. These were mainly mild to moderate reactions that disappeared within 1 to 2 weeks.
60% of patients who reported feeling some level of pain during or after their initial Restylane Defyne treatment reported it lasting 1 to 3 days.
If any symptoms last longer than 2 weeks, you should call your doctor. For more information on the potential side effects of chin filler, please review our Patient Information for Restylane Defyne.
- Restylane Defyne. Instructions for Use. Galderma Laboratories, L.P., 2023.
Anesthetic lidocaine can significantly reduce pain during and after chin filler treatment. Restylane Defyne contains lidocaine, but your injector may apply some topically before treatment as well.
When studied in a clinical setting, 60% of patients who reported feeling some level of pain during or after their initial Restylane Defyne treatment reported it lasting 1 to 3 days.
For more information on the potential side effects of chin filler, please review our Patient Information for Restylane Defyne.
- Restylane Defyne. Instructions for Use. Galderma Laboratories, L.P., 2023.
Dermal fillers can be used to
- Vleggaar D, Fitzgerald R. Dermatological implications of skin aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7:209-220
Fine lines around the mouth can be smoothed out using hyaluronic acid dermal fillers. Lines on the lips, the vertical lines that extend out from the lips, the pre-jowl portion of the marionette lines, and wrinkles starting to form at the corners of the mouth can all be softened with flexible hyaluronic acid (HA) gel technology that provides subtle, natural-looking results while restoring a more youthful-looking appearance.1
- Vleggaar D, Fitzgerald R. Dermatological implications of skin aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7:209-220
Over time, our skin thins, losing volume and firmness, which leads to appearing signs of aging, such as lines, wrinkles, and sagging. Hyaluronic acid (HA) gel dermal fillers are a non-surgical method for restoring and maintaining a more youthful-looking appearance. The volume of the filler provides support and structure for the skin. For example, Restylane Lyft, when used in the cheek, can give the cheeks needed structure for a lifted, less tired-looking appearance.1-3*
- Restylane Lyft. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Vleggaar D, Fitzgerald R. Dermatological implications of skin aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7:209-2202.
- Data on file. 05DF2004 Clinical Study Report. Galderma Laboratories, L.P., 2021.
Aging skin loses volume and firmness, which leads to telltale signs of aging like wrinkles and sagging. Hyaluronic acid (HA) gel dermal fillers provide support and structure for the skin. To combat a saggy cheek look, Restylane Lyft can give the cheek needed structure for a lifted, less tired-looking appearance, while Restylane Contour restores the natural contour, or cheek definition, for a more youthful-looking appearance.1-4*
HA gel dermal fillers provide a non-surgical method with clinically proven safety and efficacy for restoring and maintaining a more youthful-looking appearance. To see Before & After photos, please explore our Results Gallery.
- Restylane Lyft. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Restylane Contour. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Vleggaar D, Fitzgerald R. Dermatological implications of skin aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7:209-2202.
- Data on file. 05DF2004 Clinical Study Report. Galderma Laboratories, L.P., 2021.
As part of the natural aging process, volume in the hands can deteriorate over time, making them appear aged. Veins, tendons, and bones may become more visible. Hyaluronic acid dermal filler like Restylane Lyft can be used to reverse telltale signs of aging on the back of the hands, such as wrinkles and bony-looking volume loss.1,2
Some Before & After photos of patient results using filler in the back of the hands can be viewed in our Results Gallery.
- Restylane Lyft. Instructions for Use. Galderma Laboratories, L.P., 2023.
- Fabi SG, Goldman MP. Hand rejuvenation: a review and our experience. Dermatol Surg. 2012 Jul;38(7 Pt 2):1112-27. doi: 10.1111/j.1524-4725.2011.02291.x
Cost + Savings
There are many factors that affect the cost of your treatment, including:
- ASPIRE Galderma Rewards: With ASPIRE, you earn points at each treatment that can be redeemed for savings at future treatments. Any outstanding points balance on your account or unused ASPIRE reward certificates or offers will affect the cost of the treatment. Join ASPIRE today to receive your $20 Welcome Reward.
- Aesthetic Injector Pricing: Each dermatology practice, medical spa, or other practice where you might schedule an aesthetic injector may vary on pricing.
- City/Location: Price varies across location. For example, urban parts of major metropolitan areas may experience different cost trends than more rural locations.
- Number of treatment sessions needed and the amount of product used per session.
- Degree of necessary correction determined by you and your specialist.
- Discounts and special offers: It’s a good idea to ask your specialist if there are any specials or discounts available at the time of your consultation.
Meeting with an aesthetic specialist to discuss your specific goals is the best way to get an accurate idea of pricing. If you’d like to find aesthetic injectors in your area, please use our Find a Specialist search feature.
We invite you to join our loyalty program — ASPIRE Galderma Rewards — to earn points and rewards for Galderma aesthetic treatments. Every 100 points = $10 in rewards.
Be sure to ask your injector if their practice is part of the ASPIRE Rewards program!
To join the ASPIRE Galderma Rewards program, please visit ASPIRErewards.com/join-now.
You can earn ASPIRE points by:
- Receiving qualifying Galderma Aesthetic treatments
- Purchasing a qualifying product or treatment from a partner brand, such as Alastin Skincare
- Completing your ASPIRE Galderma Rewards profile
- Taking a qualifying survey
- Referring a friend who enrolls in the ASPIRE Galderma Rewards program
You may earn a maximum of 600 treatment points for a single Galderma Treatment with each Restylane® family product or qualifying Galderma Aesthetics treatments. You may earn a maximum of 1000 treatment points per visit to your healthcare professional for all qualifying treatments and purchases, including all Galderma Treatments, Qualifying Alastin Skincare Purchases, and Mentor treatments.
For more frequently asked questions about ASPIRE, please visit the ASPIRE FAQ page.
*Terms and conditions apply.
You can redeem your points for treatment certificates by tapping “Redeem” on the homepage of the ASPIRE Galderma Rewards app, or by clicking “redeem now” on a certificate displayed on the Redeem page of ASPIRErewards.com.
A confirmation window will appear, and you may proceed with the redemption or cancel it. If you choose to proceed, you’ll receive a success message. The points will be deducted from your account, and you’ll be able to view the certificate on your Rewards page.
For more frequently asked questions about ASPIRE, please visit the ASPIRE FAQ page.
Restylane products can only be administered by a licensed healthcare professional and cannot be purchased online. If you are a licensed healthcare professional wanting to purchase Restylane, please reach out to your Galderma Account Manager, or call 1-800-221-1749 to reach Galderma’s US Inside Sales office.
If you prefer to contact us via email, please reach out to inside.sales@galderma.com. In order to provide you with the most helpful possible response regarding Restylane purchases, please include this information in your email:
- Main contact’s name, phone number, and email
- Practice’s name, phone number, and email
- Practice’s address, including city, state, and ZIP code
- Any additional notes, such as products of interest or any questions you have
For more information, please visit our For Healthcare Professionals page or Galderma’s Contact page.
Have more questions?
- Restylane® - Instructions for Use
- Restylane-L® - Instructions for Use
- Restylane® Contour - Instructions for Use
- Restylane® Defyne - Instructions for Use
- Restylane® Kysse - Instructions for Use
- Restylane® Lyft - Instructions for Use
- Restylane® Refyne - Instructions for Use
- Restylane® Silk - Instructions for Use
- Restylane® Eyelight - Instructions for Use
- Restylane® - Patient Safety Information
- Restylane-L® - Patient Safety Information
- Restylane® Contour - Patient Safety Information
- Restylane® Defyne - Patient Safety Information
- Restylane® Kysse - Patient Safety Information
- Restylane® Lyft - Patient Safety Information
- Restylane® Refyne - Patient Safety Information
- Restylane® Silk - Patient Safety Information
- Restylane® Eyelight - Patient Safety Information
Important Safety Information
The Restylane family of products are indicated for patients over the age of 21, and includes Restylane®, Restylane-L®, Restylane® Lyft with Lidocaine, Restylane® Silk, Restylane® Kysse, Restylane® Refyne, Restylane® Defyne, Restylane® Contour, and Restylane® Eyelight.
Approved Uses
Restylane® and Restylane-L® are for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. Restylane® and Restylane-L® are also indicated for injection into the lips.
Restylane® Lyft with Lidocaine is for deep implantation into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds and for cheek augmentation and for the correction of age-related midface contour deficiencies. Restylane® Lyft with Lidocaine is also indicated for injection into the dorsal hand to correct volume loss.
Restylane® Silk is for lip augmentation and for correction of perioral wrinkles.
Restylane® Kysse is for lip augmentation and for correction of upper perioral wrinkles.
Restylane® Refyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds.
Restylane® Defyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe deep facial wrinkles and folds, such as nasolabial folds. Restylane® Defyne is also indicated for injection into the mid-to deep dermis (subcutaneous and/or supraperiosteal) for augmentation of the chin region to improve the chin profile in patients with mild to moderate chin retrusion.
Restylane® Contour is for cheek augmentation and for the correction of midface contour deficiencies.
Restylane® Eyelight is for the improvement of infraorbital hollowing.
Do not use if you have severe allergies with a history of severe reactions (anaphylaxis), are allergic to lidocaine or gram-positive bacterial proteins used to make hyaluronic acid, prone to bleeding, or have a bleeding disorder. The safety of use while pregnant or breastfeeding has not been studied. Tell your doctor if you have a history of scarring or pigmentation disorders as these side effects can occur with hyaluronic acid fillers. Tell your doctor if you are planning other cosmetic treatments (i.e., lasers and chemical peels) as there is a possible risk of inflammation at the injection site.
Tell your doctor if you’re taking medications that lower your body’s immune response or affect bleeding, such as aspirin or warfarin, as these medications may increase the risk of bruising or bleeding at the gel injection site. Using these products on gel injection sites with skin sores, pimples, rashes, hives, cysts, or infections should be postponed until healing is complete.
The most common side effects are swelling, redness, pain, bruising, headache, tenderness, lump formation, itching at the injection site, and impaired hand function. Delayed-onset inflammation near the site of dermal filler injections is one of the known adverse events associated with dermal fillers, and cases have been reported to occur at the dermal filler treatment site following viral or bacterial illnesses or infections, vaccinations, or dental procedures. Typically, the reported inflammation was responsive to treatment or resolved on its own. Serious but rare side effects include delayed onset infections, recurrence of herpetic eruptions, and superficial necrosis at the injection site. The risk of unintentional injection into a blood vessel is small but can occur and could result in serious complications, which may be permanent including, vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. As with all skin injection procedures, there is a risk of infection.
To report a side effect with any Restylane® product, please call Galderma Laboratories, L.P at 1-855-425-8722.
To learn more about serious but rare side effects and full Important Safety Information, visit www.RestylaneUSA.com.